JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION (Z839)
OUTSOURCE
JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION (Z839)
Also Known As:
JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION
₹7,880
About This Test
JAK2 gene mutations are important diagnostic markers for the Myeloproliferative disorder Polycythemia vera (PV). A single mutation (V617F) is found in approximately 95% of cases. Of the PV cases that are V617F-negative (approximately 5%), most are associated with mutations in a different region of the JAK2 gene within exon 12. Patients with exon 12 mutations present frequently with erythrocytosis as the predominant feature, but without concurrent elevations in the megakaryocytic or granulocytic lineages as seen in V617F-positive PV. Consequently, many exon 12 positive cases are considered clinically as Idiopathic erythrocytosis. Unlike the V617F mutation that is found in several Myeloproliferative neoplasms (PV, Essential thrombocythemia & Primary myelofibrosis), JAK2 exon 12 mutations are restricted only to cases of PV. WHO (2016) diagnostic algorithm for suspected PV now recommends JAK2 exon 12 mutation screening in patients who present with a suspicion for PV that is V617F negative.
At a Glance
Home Collection
Available
Report TAT
1 Day
Category
OUTSOURCE
Preparation / Prerequisite
3 mL (2 mL min.) Whole blood from 1 Lavender Top (EDTA) tube. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Physician prescription is mandatory.
Frequently Asked Questions
1. What Is outsourced test ?
Outsourced test are being done from Dr. Lal Path Lab. Charges and reporting time is same as of Dr. Lal Path Labs.
2. Any Preparation for the test ?
Physician prescription is mandatory.
3. Why this test is important ?
JAK2 V617F is the most common mutation in myeloproliferative neoplasms (MPNs). However, some patients with clinical signs of polycythemia vera (PV) or other MPNs may test negative for V617F. In such cases, reflex testing for JAK2 exon 12 mutations is performed to detect less common mutations causing the disease.
TAT Policy
The Turnaround Time (TAT) depends on the following factors:
- Registration date and time
- Type of scan or test
- Scan time or sample collection time
In uncommon circumstances, TAT may be delayed due to test complexity or reasons beyond our control. You will be informed of the estimated TAT at the time of registration.
