The HPV (Human Papillomavirus) test is a molecular PCR test used to detect the presence of HPV DNA in cervical or other body samples. It identifies high-risk HPV types that are associated with cervical cancer and other anogenital cancers. Often used alongside or as a co-test with Pap cytology. The test helps in screening, diagnosis, and follow-up of women with abnormal Pap smears. In men, HPV testing may be used for anal, penile, or oropharyngeal screening in specific cases. Sexually active males can also show HPV infections in oropharyngeal region and urine. Oropharyngeal squamous carcinoma (OSCC) has shown a gradual increase in male predominance due to increasing incidence of HPV infections. Routine screening for HPV DNA in females reduces the incidence of cervical cancer and in males is linked o OSCC. High-risk HPV types (especially HPV 16 and 18) cause most cervical cancers. High risk human papilloma viruses genotypes are 16,18,31,33,35,39,45,51,52,56,58,59,66 & 68 and low risk genotypes are 6 & 11.